Ensite Vascular SiteSeal

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SiteSeal® – The Extravascular Closure Solution for Complex EP & Large-Bore Access

SiteSeal is FDA-cleared to close any sheath size (arterial/venous) with nothing left behind, addressing key limitations of traditional VCDs in electrophysiology and large-bore cases. Its external compression design ensures reliable hemostasis, immediate re-access, and rapid recovery — ideal for high-volume EP labs.

Vascular

Core Clinical Advantages

  • No sheath size restriction
Handles large-bore (EVAR/TEVAR/TAVI) and multiple sheaths in one vessel
  • Extravascular only
No anchor/plug/suture left behind → reduced embolization/infection risk
  • EP performance
Zero hematomas/delayed bleeding in comparative 138-patient study
  • Patient mobility
Immediate head elevation, unrestricted leg movement, early ambulation
  • Procedural simplicity
Rapid deployment, immediate re-access if required
  • Inclusive
Effective in morbid obesity, calcification, all patient types

Efficiency & Cost Benefits

  • Single device per access site → lower per-case cost vs multi-device competitors
  • Reduced recovery time → improved lab throughput & patient satisfaction

Comparison

Feature

SiteSeal®
Perclose
ProGlide

Angio-Seal

Mynx

Vascade
MVP
Figure of Eight
Implant left behind

No

Yes
(suture)
Yes
(plug)
Yes
(sealant)
Yes
(collagen)
No
Sheath size limitation

None

Limited
Limited
Limited
Limited

Not preferred for Large bore

Works across all anatomies
Yes
No
No
No
No
No
Devices per access site
1 — including multi-sheath
2-3 typical
2-3 typical
2-3 typical
2-3 typical
1
EP study: zero hematomas
0%
<2%
<5.6%
<10.3%
<5%
<5.5%
Immediate re-access
Yes
No
No
No
No
Yes
Early ambulation*

2 hrs.

2.3 hrs.

2.5 hrs.

2.6 hrs.

2.3 hrs.

4-6 hrs.

* Abstract 14277: Comparison of Three Vascular Closure Devices for Vascular Access Closure After Cardiac Electrophysiology Procedures Carola Gianni, Thomas Chafizadeh, Domenico G Della Rocca, Sanghamitra Mohanty, Amin Al-Ahmad, J D Burkhardt, G J Gallinghouse, Rodney P Horton, Patrick M Hranitzky, Javier E Sanchez, and Andrea Natale Circulation Volume 146, Number Suppl_1

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SiteSeal® Placement in EP Access

SiteSeal® Removal & Hemostasis
Confirmation

Why Patients Love SiteSeal®:
Comfort, Safety, and Peace of Mind

Patient-Centric Care with SiteSeal® – Ensuring optimal outcomes and a smooth recovery for every patient, setting new standards in patient care and clinical outcomes.

Rapid Recovery and Enhanced Comfort
Significantly reduce recovery time for EP procedures. SiteSeal® allows immediate mobility, eating, and drinking for a more comfortable recovery.
Ensite Vascular
Nothing Left Behind, Nothing Left to Chance

Unlike other VCDs that leave plugs, anchors, or collagen inside the vessel, SiteSeal® achieves hemostasis with nothing remaining at the access site, reducing long-term complication risks.

Follow-Up Care Tailored to You
Minimize complications with SiteSeal®. Follow your doctor’s instructions for a safe recovery.
Designed for All Patients
FDA cleared for arterial and venous closures, SiteSeal® adapts to any EP procedure and fits patients of all sizes.
Rapid Recovery and Enhanced Comfort
Significantly reduce recovery time for EP procedures. SiteSeal® allows immediate mobility, eating, and drinking for a more comfortable recovery.
Ensite Vascular

Nothing Left Behind, Nothing Left to Chance

Unlike other VCDs that leave plugs, anchors, or collagen inside the vessel, SiteSeal® achieves hemostasis with nothing remaining at the access site, reducing long-term complication risks.

Follow-Up Care Tailored to You

Minimize complications with SiteSeal®. Follow your doctor’s instructions for a safe recovery.

Designed for All Patients

FDA cleared for arterial and venous closures, SiteSeal® adapts to any EP procedure and fits patients of all sizes.